10.0253/TUPRINTS-00003858
UNSPECIFIED
Re-scanning in scanned ion beam therapy in the presence of organ motion
Therapeutic dose application by highly tumor-conformal scanned ion beam radiation therapy is
currently in most cases not possible for indications which exhibit tumor motion. Due to interference
effects, the dose application is likely to be distorted so that treatment is not safely possible.
Distorted dose profiles can be improved by means of statistical averaging - the corresponding
technique is known as re-scanning and was investigated in this work.
Carbon ion treatment planning studies for five lung cancer cases and six different re-scanning
flavors were performed. The data show that at least the techniques breath-sampled and random-time-
delay re-scanning should be able to compensate dose inhomogeneities sufficiently as to
enable patient treatment.
Re-scanning was technically implemented in a research version. Experiments were performed
to test the implementation, to verify the dose application and to investigate the motion mitigation
efficiency. The corresponding dose levels showed only small deviations compared to
the therapy delivery mode for stationary targets. The experimental data for motion mitigation
strengthened the findings of the simulations. Over- and underdosage can be efficiently reduced
using re-scanning.
Müssig, Dirk
Dirk
Müssig
CC-BY-NC-ND 2.5 de - Creative Commons, Attribution Non-commerical, No-derivatives
2014
Thesis