10.0859/INTERVALS.XVBXDL.2
Iskandar, Anita
Anita
Iskandar
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Mathis, Carole
Carole
Mathis
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Martin, Florian
Florian
Martin
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Leroy, Patrice
Patrice
Leroy
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Sewer, Alain
Alain
Sewer
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Majeed, Shoaib
Shoaib
Majeed
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Kuehn, Diana
Diana
Kuehn
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Trivedi, Keyur
Keyur
Trivedi
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Grandolfo, Davide
Davide
Grandolfo
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Cabanski, Maciej
Maciej
Cabanski
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Guedj, Emmanuel
Emmanuel
Guedj
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Merg, Céline
Céline
Merg
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Frentzel, Stefan
Stefan
Frentzel
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Ivanov, Nikolai
Nikolai
Ivanov
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Peitsch, Manuel
Manuel
Peitsch
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Hoeng, Julia
Julia
Hoeng
PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchâtel, Switzerland
Assessment of Acute THS 2.2 Aerosol Exposure in in vitro Human Nasal Epithelial Cultures
INTERVALS
2019
Study in the INTERVALS database
Iskandar, Anita
Anita
Iskandar
2017-12-28
2019-03-25
To assess the biological impact of 3R4F smoke and THS 2.2 aerosol, a series of five experimental repetitions was conducted. The repetition was performed to increase the robustness of the impact assessment. Nasal epithelial cultures were exposed to comparable doses of 3R4F smoke and THS 2.2 aerosol. In addition, a high dose of THS 2.2 was applied at a target nicotine concentration of 0.44 mg/L aerosol). Using the Vitrocell® Dilution/Distribution module, these specific nicotine concentrations were applied to the nasal cultures by diluting 3R4F smoke or THS 2.2 aerosol during using the Vitrocell® exposure system.