10.17863/CAM.10273
Hennequin, Guillaume
0000-0002-7296-6870
Agnes, EJ
Vogels, TPV
Inhibitory Plasticity: Balance, Control, and Codependence
Apollo - University of Cambridge Repository (staging)
2017
inhibition
GABA
synaptic plasticity
network dynamics
feedback control
modeling
Apollo - University of Cambridge Repository (staging)
Apollo - University of Cambridge Repository (staging)
2017-07
Article
Inhibitory neurons, although relatively few in number, exert powerful control over brain circuits. They stabilize network activity in the face of strong feedback excitation and actively engage in computations. Recent studies reveal the importance of a precise balance of excitation and inhibition in neural circuits, which often requires exquisite fine-tuning of inhibitory connections. We review inhibitory synaptic plasticity and its roles in shaping both feedforward and feedback control. We discuss the necessity of complex, codependent plasticity mechanisms to build nontrivial, functioning networks, and we end by summarizing experimental evidence of such interactions.
The writing of this review was supported by a Wellcome Trust Seed Award to G.H. (202111/Z/16/Z), a Sir Henry Dale Wellcome Trust and Royal Society Grant to T.P.V. (WT100000), and a postdoctoral grant from Brazilian CNPq to E.J.A. (235144/2014-2).