10.22025/CAMSTAG2.55835
Michielse, Stijn
Lange, Iris
Bakker, Jindra
Goossens, Liesbet
Verhagen, Simone
Papalini, Silvia
Wichers, Marieke
Lieverse, Ritsaert
Schruers, Koen
van Amelsvoort, Therese
van Os, Jim
Murray, Graham K
Marcelis, Machteld
Reward anticipation in individuals with subclinical psychotic experiences: A functional MRI approach.
Apollo - University of Cambridge Repository (staging)
2019
Emerging adults
Mild psychopathology
Monetary reward
Reward anticipation
Subclinical psychotic experiences
fMRI
Apollo - University of Cambridge Repository (staging)
Apollo - University of Cambridge Repository (staging)
2019-12-04
2019-12-04
2019-11-01
2018-12-14
2019-12-04
Article
https://dspace-staging.lib.cam.ac.uk/handle/1810/308567
1873-7862
31685359
S0924-977X(19)31713-4
10.1016/j.euroneuro.2019.10.002
Previous research in patients with psychotic disorder has shown widespread abnormalities in brain activation during reward anticipation. Research at the level of subclinical psychotic experiences in individuals unexposed to antipsychotic medication is limited with inconclusive results. Therefore, brain activation during reward anticipation was examined in a larger sample of individuals with subclinical psychotic experiences (PE). Participants in the PE-group were included based on CAPE scores. A sample of emerging adults aged 16-26 years (n = =47) with PE and healthy controls (HC) (n = =40) underwent fMRI scanning. The Monetary Incentive Delay task was conducted with cues related to win, loss or neutral conditions. fMRI nonparametric tests were used to examine the reward versus neutral cue contrast. A significant main effect of the large win (€3.00) > neutral contrast was found in both groups showing activation in many brain areas, including classic reward regions. Whole brain analysis on the group comparison regarding the large win > neutral contrast showed significantly decreased activation in the right insula, putamen and supramarginal gyrus in the PE-group compared to controls. There was no group difference in the hypothesized reward-related region. Decreased activation in the right insula, putamen and supramarginal gyrus during reward anticipation in individuals with PE may be consistent with altered processing of sensory information, related to decreased emotional valuing and motivational tendencies and/or altered motor-cognitive processes. The absence of group differences in striatal activation suggests that activation here is intact in the earliest stages of psychosis and may exhibit progressive deterioration in as the disease develops. [Abstract copyright: Copyright © 2019. Published by Elsevier B.V.]