10.22025/CAMSTAG2.56439
Gallipoli, Paolo
0000-0001-7254-2253
Giotopoulos, George
Tzelepis, Konstantinos
Costa, Ana S. H.
Vohra, Shabana
Medina-Perez, Paula
Basheer, Faisal
Marando, Ludovica
Di Lisio, Lorena
Dias, Joao M. L.
Yun, Haiyang
Sasca, Daniel
Horton, Sarah J.
Vassiliou, George
Frezza, Christian
Huntly, Brian J. P.
0000-0003-0312-161X
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
Apollo - University of Cambridge Repository (staging)
2018
Immunology
Cell Biology
Biochemistry
Hematology
Apollo - University of Cambridge Repository (staging)
Apollo - University of Cambridge Repository (staging)
2019-12-04
2019-12-04
2018-04-12
2019-12-04
Article
0006-4971
https://dspace-staging.lib.cam.ac.uk/handle/1810/309171
1528-0020
10.1182/blood-2017-12-820035
Key Points FLT3ITD TK inhibition impairs glycolysis and glucose utilization without equally affecting glutamine metabolism. Combined targeting of FLT3 TK activity and glutamine metabolism decreases FLT3ITD mutant cells leukemogenic potential in vitro and in vivo.